Fannie Enfield was appointed organizing chapter regent at the 1920 Continental Congress. She issued a call to fifteen qualified members-at-large to form a chapter. The group met for the first time on September 29, 1921. It was at that meeting the members selected the name, Bedford Chapter, NSDAR.

In September 1927, the Pennsylvania State Society State Conference was held at the Bedford Springs Hotel in Bedford, PA under the guidance of the chapters second regent, Daisy Huzzard Jordan (1924-1927), the chapter served as host chapter of the event, in cooperation with other local area chapters. The conference was honored by the attendance of Grace H. Brosseau, President General, and other national officers. Two of the chapter members served as pages.